Friday, 20th September 2019
08:30 Opening remarks and welcome
Daniel Pauleikhoff (Münster)
Frank G. Holz (Bonn)
08:45 - 10:15 1st Session - AMD basics
Moderators:
SriniVas Sadda (Los Angeles/USA)
Steffen Schmitz-Valkenberg (Bonn)
1 L
Alan C. Bird (London/GB)
Why the macula? – Learnings from the MacTel project
2 L
Philip J. Luthert (London/GB)
Cellular structures - computational biology of the macula
3 L
Christine A. Curcio, D. Kar, D.M. Dacey, D.M.G. Anderson, A. Kotnala, K.L. Schey (Birmingham/USA., Seattle/USA, Nashville/USA)
Molecular microarchitecture of macula in health and AMD
4 L
Robert Mullins (Iowa City/USA)
Addressing choriocapillaris degeneration in AMD: Cause, consequences, and potential therapies
5 L
Sandra Liakopoulos (Cologne/D)
Macular Imaging - Morphology and changes in AMD and aging?
6 L
Marius Ueffing (Tübingen/D)
Using cell lines - identify, model and validate AMD risk factors and disease drivers
7 P
Anita de Breuk, I.E. Acar, E. Kersten, M.M.V.A.P. Schijvenaars, M.A. Meester-Smoor, C. Delcourt, C.C.W. Klaver,
J. Monés, D. Pauleikhoff, R. Silva, S. Fauser, C.B. Hoyng, M.J.H. Coenen, A.I. den Hollander, EYE-RISK Consortium
(Nijmegen/NL, Rotterdam/NL, Bordeaux/F, Barcelona/E, Münster/D, Coimbra/P, Cologne/D)
Development of a Genotyping Assay for AMD: The EYE-RISK Consortium
8 P
Thomas J. Heesterbeek, E.K. de Jong, I.E. Acar, J.M.M. Groenewoud, B. Liefers, C.I. Sánchez,
T. Peto, C.B. Hoyng, D. Pauleikhoff, H.W. Hense, A.I. den Hollander
(Nijmegen/NL, Belfast/GB, Münster/D)
Genetic Risk Score has added value over initial clinical grading stage in predicting disease progression in patients
with non-advanced age-related macular degeneration – The Muenster Aging and Retina Study (MARS)
10:15 - 10:45 - Coffee break in the industrial exhibition area
10:45 - 12:30 2nd Session - Genetics and risk factors of AMD
Moderators:
Carel B. Hoyng (Nijmegen/NL)
Bernhard H.F. Weber (Regensburg/D)
9 L
Bernhard H.F. Weber (Regensburg/D)
AMD – Searching for targeted therapies
10 L
Carel B. Hoyng (Nijmegen/NL)
AMD genotype-phenotype correlation?
11 L
Magda A. Meester-Smoor, C.C.W. Klaver (Rotterdam/NL)
EyeRisk Study – risk factors for AMD phenotypes and progression?
12 L
Giovanni Staurenghi (Milan/I)
How to differentiate GA phenotypes – the CAM initiative
13 L
Frank G. Holz, S. Schmitz-Valckenberg, M. Schmid, G.S. Rubin, H. Dunbar, A. Tufail, D.P. Crabb, A. Binns,
C.I. Sánchez, P. Margaron, G. Normand, M.K. Durbin, U.F.O. Luhmann, P. Zamiri, J. Cunha-Vaz, F. Asmus F, R.P. Finger,
on behalf of the MACUSTAR consortium Intermediate AMD – the Macustar project
14 L
Steffen Schmitz-Valkenberg (Bonn/D)
Challenges in phenotyping geographic atrophy
15 L
Andrew Lotery, J R. Sutton, S. Khandhadia, G. Menon, C. Bailey, S. Sivasprasad, Q. Mohamed, P. Bishop, P. Charbel Issa,
D. Steel, T. Peto, W. Amoaku, R. Arora, P. Prakash, W. Innes, R. Maclaren, D. Kavanagh
(Southampton/GB, Camberley/GB, Bristol/GB, London/GB, Cheltenham/GB, Manchester/GB, Oxford/GB,
Sunderland/GB, Nottingham/GB, Salisbury/GB, Harlow/GB, Newcastle/GB)
Rare genetic variants in geographic atrophy
16 L
Sobha Sivaprasad (London/GB)
Early loss of color vision on drusen and reticular pseudodrusen
12:30 - 13:45 - Lunch
13:45 - 15:45 3rd Session - Complement, inflammation and cellular energetics in AMD
Moderators:
Philip J. Luthert (London/GB)
Marius Ueffing (Tübingen/D)
17 L
Gregory S. Hageman, C.M. Pappas, R.A. Anstadt, J.Liu, B.L. Williams, N.A. Seager, J.L. Hageman,
M. Zouache, K. Curtin, B.T. Richards (Salt Lake City/USA)
Complement-directed AMD is a distinct, genotype-driven subset of the disease
18 L
Bradley D. Gelfand, J. Ambati (Charlottesville/USA)
Inflammasome in AMD
19 L
Tim U. Krohne, L. Wang, S. Schmidt, J. Rossa, P.P. Larsen, J.H. Meyer, W.R. Roush, E. Latz, F.G. Holz (Bonn/D, Boston/USA)
NLRP3 inflammasome as a therapeutic target in AMD
20 L
Glen Jeffery (London/GB)
Mitochondrial decline precedes phenotype development in the complement factor H
mouse model of retinal degeneration but can be corrected by near infrared light
21 L
Imre Lengyel (Belfast/IRL)
Is mineralization a major factor in drusen pathogenesis?
22 P
Martin Zinkernagel, D. Zysset, I. Keller, L. Berger, B. Yilmaz, S. Wolf (Bern/CH)
Associations of the intestinal microbiome with AMD
23 P
Ilhan Erkin Acar, L. Lores de Motta, M.A. Meester, S. Ajana, D. Pauleikhoff, S. Fauser, C.B. Hoyng,
C. Delcourt, C.C.W. Klaver, T.E. Galesloot, A.I. den Hollander
(Nijmegen/NL, Rotterdam/NL, Bordeaux/F, Münster/D, Cologne/D)
Metabolomics identifies lipoprotein subclasses and dietary metabolites that are associated with AMD: The EYE-RISK Consortium
24 P
Yara Lechanteur, T. Heesterbeek, L. Lorés-Motta, T. Schick, M. Daha, L. Altay, S. Liakopoulos, D. Smailhodzic,
A. den Hollander, C. Hoyng, E. de Jong, B. Klevering
(Nijmegen/NL, Cologne/D, Leiden/NL)
Complement activation levels are related to disease stage in AMD
25 P
Laura Lorés de Motta, V. Cipriani, F. He, D. Fathalla, S. McHarg, N. Bayatti, I.E. Acar, C.C.B. Hoyng, S. Fauser,
A. Moore, J.R.W. Yates, P. Morgan, E.K. de Jong, A.I. den Hollander, P.N. Bishop, S.J. Clark
(Nijmegen/NL, London/GB Manchester/GB, Cardiff/GB, Cologne/D, Basel/CH, San Francisco/USA, Cambridge/GB,)
Factor H-Related Protein 4 (FHR-4) drives complement dysregulation in AMD
26 P
Anja Schlecht, P. Wieghofer, P. Zhang, S. Bonvea, M. Gruber, R. Sankowski, G. Schlunck, H. Agostini, M. Prinz, C. Lange
(Freiburg i.Br./D, Leipzig/D)
Identification of myeloid cell populations at sites of laser-induced choroidal neovascularization by single-cell profiling
27 P
Alexa Klettner, K. Winkelmann, A. Brinkmann, T. Käckenmeister, J. Roider (Kiel/D)
Effect of long-term inflammation on viability and function of RPE cells
15:45 - 16:15 Coffee break
16:15 - 17:40 4th Session - Neurobiology of the outer retina I
Moderators:
Deborah A. Ferrington (Minneapolis/USA)
John G. Flannery (Berkley/USA)
28 L
Thomas Langmann, A. Wolf (Cologne/D)
Microglia as important part of the retina: Its role in AMD
29 P
Clemens Lange, A. Schlecht, S. Boneva, J. Wolf, P. Zhang, G. Prinz, R. Horres, F. Bucher, C. Auw-Haedrich,
L. Hansen, A. Stahl, I. Hilgendorf, H. Agostini, P. Wieghofer, G. Schlunck
(Freiburg i.Br./D, Frankfurt/D, Greifswald/D, Leipzig/D)
Transcriptomic characterization of human choroidal neovascular membranes
identifies calprotectin as a novel biomarker for patients with AMD
30 L
Rajendra S. Apte (St. Louis/USA)
Animal model for AMD interfering lipid trafficking
31 P
Christian Grimm, F. Storti, T. Hornemann, A. den Hollander, C. Maugeais
(Schlieren/CH, Nijmegen/NL, Basel/CH)
Impaired function of the lipid transporters ABCA1 and ABCG1 in the RPE leads to an AMD-like phenotype in mice
32 L
Nicolas Bazan (New Orleans/USA, Stockholm/S)
Elovanoids are novel photoreceptor survival signals relevant to AMD
33 L
Clare Futter (London/GB)
Lysosome dysfunction in the RPE and its role in early AMD
34 L
Gerard A. Lutty, S. Ogura, R. Baldeosingh, D.S. McLeod, M.M. Edwards, I.A. Bhutto (Baltimore/USA)
Mast cell involvement in geographic atrophy
17:40 - 18:00 Lecture in memory of Gerhard Zinser
Moderator:
Frank G. Holz
Daniel Pauleikhoff
35
Josef F. Bille (Heidelberg/D)
Past, present and new horizons in imaging analysis - The heritage of Gerhard Zinser
19:30 - Reception at “Brenner’s Park Hotel”
20:00 - Gala dinner
Saturday, 21th September 2019
08:30 - 10:00 5th Session - Neurobiology of the outer retina II
Moderators:
Thomas Langmann (Cologne/D)
Anneke den Hollander (Nijmegen/NL)
36 L
Janet Sparrow (Boston/USA)
Is lipofuscin a relevant factor in the pathogenesis of AMD?
37 P
Thomas Ach, K. Bermond, J. A. Gambril, C. Wobbe, A. Berlin,
R. Heintzmann, K.R. Sloan, C.A. Curcio (Würzburg/D, Jena/D, Birmingham/USA)
Cellular and subcellular changes in the RPE: from normal aging to early signs of AMD
38 L
Deborah A. Ferrington (Minneapolis/USA)
Primary RPE cultures from donors with AMD
39 P
Stephanie C. Joachim, N. Wagner, M. Gammel, A. Greulich, S. Reinehr, J. Hurst, H.B. Dick, S. Schnichels (Bochum/D, Tübingen/D)
Novel porcine organ culture model for AMD research
40 L
Anneke den Hollander (Nijmegen/NL)
Understanding disease mechanisms in AMD: From serum biomarkers to an organ-on-a-chip model for AMD
41 L
John G. Flannery, M.H. Berry, A. Holt, A. Salari, J. Veit, M. Visel, J. Levitz, K. Aghi, B. Gaub, B. Sivyer, E. Isacoff
(California/USA, Oregon/USA, New York/USA, Zürich/CH)
Restoration of high-sensitivity and adapting vision with a cone opsin
42 L
Volker Busskamp (Bonn/D)
Programming human stem cells to cone photoreceptors
43 P
Giuliana Gagliardi, D.M. Feitosa-Afonsso, Y.B. Arik, J. Heesterbeek, C.B. Hoyng, A.D. van der Meer, A.I. den Hollander
(Nijmegen/NL, Enschede/NL)
Using human-induced pluripotent stem cells for modelling the blood-retinal-barrier on-a-chip
10:00 - 10:45 6th Session - Rapid Fire Presentations
11:15 - 13:00 7th Session - Phenotyping AMD: Advances in Imaging
Moderators:
Richard F. Spaide (New York/USA)
Giovanni Staurenghi (Milan/I)
44 L
SriniVas Sadda (Los Angeles/USA)
Choriocapillaris status as a risk factor in AMD
45 L
Philip J. Rosenfeld (Miami/USA)
Choriocapillaris imaging using SS-OCT angiography in AMD
46 P
Martin Hammer, R. Schultz, D. Meller (Jena/D)
Clinicopathologic comparison of fluorescence lifetimes and spectral characteristics in AMD
47 L
Sebastian Wolf, C. Dysli, M.S. Zinkernagel (Bern/CH)
Fluorescence lifetimes in AMD
48 P
Lydia Sauer, A.S. Vitale, N.K. Modersitzki, E.D. Hansen, C. B. Komanski, P.S. Bernstein (Salt Lake City/USA)
Imaging of AMD with FLIO
49 L
Adam Dubis (London/GB)
Adaptive optics photoreceptor imaging, function and survival in AMD
50 P
Thomas Theelen, P.P.A. Dhooge, T.W.F. Mulders, C.B. Hoyng (Nijmegen/NL)
In vivo photoreceptor imaging by non-adaptive optics confocal scanning laser ophthalmoscopy
51 P
R. Theodore Smith, K.B. Freund (New York City/USA)
Quantitative fundus autofluorescence (qAF) of GA secondary to AMD
52 L
Daniel F. Martin (Cleveland/USA)
Why did GA trials fail - how to overcome obstacles?
53 P
Victor Chong (Ingelheim/D)
Neuroprotection as a therapeutic option for GA
13:00 - 14:00 - Lunch
14:00 - 17:30 8th Session - Dissecting AMD: Novel approaches
Moderators:
Frank G. Holz (Bonn/D)
Daniel Pauleikhoff (Mpnster/D)
54 L
Adnan Tufail (London/GB)
Application of deep learning-based automated segmentation in OCT on AMD
55 L
Aaron Lee (Washington/USA)
Deep learning applications with OCT in AMD
56 L
Karl Csaky, M. Oulette, C. Clark (Dallas/USA, Plano/USA)
Developing human based intuitive deep learning
algorithms for analyzing intermediate AMD OCT-Images
57 L
Glenn J. Jaffe (Durham/GB)
Challenges of clinical relevant phenotyping of exudative AMD
58 L
Richard F. Spaide (New York/USA)
OCT-angiography – dissecting neovasular AMD
59 L
Giuseppe Querques, R. Sacconi, V. Capuano, A. Carnevali, D. Colantuono, M. Battista, E. Borrelli,
A. Miere, M.Parravano, E. Costanzo, L. Querques, E.H. Souied, F. Bandello
(Milan/Creteil/F, Catanzaro/I, Rome/I)
„Quiescent“ CNV in AMD – characteristics and consequences
60 P
Maximilian Pfau, L. von der Emde, C. Dysli, P.T. Möller, S. Thiele, M. Lindner, M. Schmid,
S. Schmitz-Valckenberg, F.G. Holz, M. Fleckenstein
(Bonn/D, Bern/CH, Oxford/GB)
Type-1 choroidal neovascularization reduces the progression of atrophy in eyes with AMD
61 L
David Sarraf (Los Angeles/USA)
Mechanisms and pathways of PED development in neovascular AMD
62 L
K. Bailey Freund (New York City/USA)
Type 3 CNV – a specific phenotype?
63 L
John Marshall (London/GB)
Can a nanosecond beam modulated laser improve transport mechanisms and delaying progression towards late AMD?
64 L
Robyn Guymer - LEAD study team (Melbourne/AUS)
Natural history and modulation of drusen by laser:
The LEAD randomized controlled trial of sub-threshold nanosecond laser intervention in AMD
65 L
Eric Souied (Paris/F)
Scarring of CNV – differentiation by multimodal imaging?
66 L
Daniel Pauleikhoff, M.L. Farecki, H. Faatz, K. Rothaus, G. Spital, A. Lommatzsch (Münster/D)
Mathematical characterization of CNV before and under anti-VEGF-therapy
67 L
Usha Chakravarthy, B. Reeves, R. Evans, C. Rogers (Belfast/GB, Bristol/GB)
Extended follow up from the IVAN trial
68 P
Heinrich Gerding (Olten/CH)
10 years anti-VEGF treatment outcomes on neovascular AMD
69 L
Ricarda G. Schumann, V. Deiters, S.R. Günther, D. Vogt, J. Siedlecki, S.G. Priglinger (Munich/D)
Long-term visual acuity outcomes and anatomic results from anti-VEGF-therapy in patients with neovascular AMD in a real-life setting
70 P
Jakob Siedlecki, C. Fischer, B. Schworm, T.C. Kreutzer, K. Kortüm, R. Schumann, A. Wolf, S.G. Priglinger (Munich/D)
Long-term incidence of macular atrophy and clinical outcomes in neovascular AMD managed to sub-retinal fluid only
17:30 Adjourn
Frank G. Holz
Daniel Pauleikhoff
Rahmenprogramm
Friday, September 20th 2019at 19.30 Reception
20.00 Gala dinner Orangerie at Brenner’s Parkhotel Schillerstraße 4-6, Baden-Baden
Musical entertainment by the Tommy Wetzel Combo
Price per person (incl. dinner and drinks): Regular € 65 Resident/Fellow/Student € 45
610
Bausch + Lomb