Friday, 20th September 2019

08:30 Opening remarks and welcome
Daniel Pauleikhoff (Münster)
Frank G. Holz (Bonn)

08:45 - 10:15 1st Session - AMD basics
Moderators:
SriniVas Sadda (Los Angeles/USA)
Steffen Schmitz-Valkenberg (Bonn)

1 L
Alan C. Bird (London/GB)
Why the macula? – Learnings from the MacTel project

2 L
Philip J. Luthert (London/GB)
Cellular structures - computational biology of the macula

3 L
Christine A. Curcio, D. Kar, D.M. Dacey, D.M.G. Anderson, A. Kotnala, K.L. Schey (Birmingham/USA., Seattle/USA, Nashville/USA)
Molecular microarchitecture of macula in health and AMD

4 L
Robert Mullins (Iowa City/USA)
Addressing choriocapillaris degeneration in AMD: Cause, consequences, and potential therapies

5 L
Sandra Liakopoulos (Cologne/D)
Macular Imaging - Morphology and changes in AMD and aging?

6 L
Marius Ueffing (Tübingen/D)
Using cell lines - identify, model and validate AMD risk factors and disease drivers

7 P
Anita de Breuk, I.E. Acar, E. Kersten, M.M.V.A.P. Schijvenaars, M.A. Meester-Smoor, C. Delcourt, C.C.W. Klaver,
J. Monés, D. Pauleikhoff, R. Silva, S. Fauser, C.B. Hoyng, M.J.H. Coenen, A.I. den Hollander, EYE-RISK Consortium
(Nijmegen/NL, Rotterdam/NL, Bordeaux/F, Barcelona/E, Münster/D, Coimbra/P, Cologne/D)
Development of a Genotyping Assay for AMD: The EYE-RISK Consortium

8 P
Thomas J. Heesterbeek, E.K. de Jong, I.E. Acar, J.M.M. Groenewoud, B. Liefers, C.I. Sánchez,
T. Peto, C.B. Hoyng, D. Pauleikhoff, H.W. Hense, A.I. den Hollander
(Nijmegen/NL, Belfast/GB, Münster/D)
Genetic Risk Score has added value over initial clinical grading stage in predicting disease progression in patients
with non-advanced age-related macular degeneration – The Muenster Aging and Retina Study (MARS)

10:15 - 10:45 - Coffee break in the industrial exhibition area

10:45 - 12:30 2nd Session - Genetics and risk factors of AMD
Moderators:
Carel B. Hoyng (Nijmegen/NL)
Bernhard H.F. Weber (Regensburg/D)

9 L
Bernhard H.F. Weber (Regensburg/D)
AMD – Searching for targeted therapies

10 L
Carel B. Hoyng (Nijmegen/NL)
AMD genotype-phenotype correlation?

11 L
Magda A. Meester-Smoor, C.C.W. Klaver (Rotterdam/NL)
EyeRisk Study – risk factors for AMD phenotypes and progression?

12 L
Giovanni Staurenghi (Milan/I)
How to differentiate GA phenotypes – the CAM initiative

13 L
Frank G. Holz, S. Schmitz-Valckenberg, M. Schmid, G.S. Rubin, H. Dunbar, A. Tufail, D.P. Crabb, A. Binns,
C.I. Sánchez, P. Margaron, G. Normand, M.K. Durbin, U.F.O. Luhmann, P. Zamiri, J. Cunha-Vaz, F. Asmus F, R.P. Finger,
on behalf of the MACUSTAR consortium Intermediate AMD – the Macustar project

14 L
Steffen Schmitz-Valkenberg (Bonn/D)
Challenges in phenotyping geographic atrophy

15 L
Andrew Lotery, J R. Sutton, S. Khandhadia, G. Menon, C. Bailey, S. Sivasprasad, Q. Mohamed, P. Bishop, P. Charbel Issa,
D. Steel, T. Peto, W. Amoaku, R. Arora, P. Prakash, W. Innes, R. Maclaren, D. Kavanagh
(Southampton/GB, Camberley/GB, Bristol/GB, London/GB, Cheltenham/GB, Manchester/GB, Oxford/GB,
Sunderland/GB, Nottingham/GB, Salisbury/GB, Harlow/GB, Newcastle/GB)
Rare genetic variants in geographic atrophy

16 L
Sobha Sivaprasad (London/GB)
Early loss of color vision on drusen and reticular pseudodrusen

12:30 - 13:45 - Lunch

13:45 - 15:45 3rd Session - Complement, inflammation and cellular energetics in AMD
Moderators:
Philip J. Luthert (London/GB)
Marius Ueffing (Tübingen/D)

17 L
Gregory S. Hageman, C.M. Pappas, R.A. Anstadt, J.Liu, B.L. Williams, N.A. Seager, J.L. Hageman,
M. Zouache, K. Curtin, B.T. Richards (Salt Lake City/USA)
Complement-directed AMD is a distinct, genotype-driven subset of the disease

18 L
Bradley D. Gelfand, J. Ambati (Charlottesville/USA)
Inflammasome in AMD

19 L
Tim U. Krohne, L. Wang, S. Schmidt, J. Rossa, P.P. Larsen, J.H. Meyer, W.R. Roush, E. Latz, F.G. Holz (Bonn/D, Boston/USA)
NLRP3 inflammasome as a therapeutic target in AMD

20 L
Glen Jeffery (London/GB)
Mitochondrial decline precedes phenotype development in the complement factor H
mouse model of retinal degeneration but can be corrected by near infrared light

21 L
Imre Lengyel (Belfast/IRL)
Is mineralization a major factor in drusen pathogenesis?

22 P
Martin Zinkernagel, D. Zysset, I. Keller, L. Berger, B. Yilmaz, S. Wolf (Bern/CH)
Associations of the intestinal microbiome with AMD

23 P
Ilhan Erkin Acar, L. Lores de Motta, M.A. Meester, S. Ajana, D. Pauleikhoff, S. Fauser, C.B. Hoyng,
C. Delcourt, C.C.W. Klaver, T.E. Galesloot, A.I. den Hollander
(Nijmegen/NL, Rotterdam/NL, Bordeaux/F, Münster/D, Cologne/D)
Metabolomics identifies lipoprotein subclasses and dietary metabolites that are associated with AMD: The EYE-RISK Consortium

24 P
Yara Lechanteur, T. Heesterbeek, L. Lorés-Motta, T. Schick, M. Daha, L. Altay, S. Liakopoulos, D. Smailhodzic,
A. den Hollander, C. Hoyng, E. de Jong, B. Klevering
(Nijmegen/NL, Cologne/D, Leiden/NL)
Complement activation levels are related to disease stage in AMD

25 P
Laura Lorés de Motta, V. Cipriani, F. He, D. Fathalla, S. McHarg, N. Bayatti, I.E. Acar, C.C.B. Hoyng, S. Fauser,
A. Moore, J.R.W. Yates, P. Morgan, E.K. de Jong, A.I. den Hollander, P.N. Bishop, S.J. Clark
(Nijmegen/NL, London/GB Manchester/GB, Cardiff/GB, Cologne/D, Basel/CH, San Francisco/USA, Cambridge/GB,)
Factor H-Related Protein 4 (FHR-4) drives complement dysregulation in AMD

26 P
Anja Schlecht, P. Wieghofer, P. Zhang, S. Bonvea, M. Gruber, R. Sankowski, G. Schlunck, H. Agostini, M. Prinz, C. Lange
(Freiburg i.Br./D, Leipzig/D)
Identification of myeloid cell populations at sites of laser-induced choroidal neovascularization by single-cell profiling

27 P
Alexa Klettner, K. Winkelmann, A. Brinkmann, T. Käckenmeister, J. Roider (Kiel/D)
Effect of long-term inflammation on viability and function of RPE cells

15:45 - 16:15 Coffee break

16:15 - 17:40 4th Session - Neurobiology of the outer retina I
Moderators:
Deborah A. Ferrington (Minneapolis/USA)
John G. Flannery (Berkley/USA)

28 L
Thomas Langmann, A. Wolf (Cologne/D)
Microglia as important part of the retina: Its role in AMD

29 P
Clemens Lange, A. Schlecht, S. Boneva, J. Wolf, P. Zhang, G. Prinz, R. Horres, F. Bucher, C. Auw-Haedrich,
L. Hansen, A. Stahl, I. Hilgendorf, H. Agostini, P. Wieghofer, G. Schlunck
(Freiburg i.Br./D, Frankfurt/D, Greifswald/D, Leipzig/D)
Transcriptomic characterization of human choroidal neovascular membranes
identifies calprotectin as a novel biomarker for patients with AMD

30 L
Rajendra S. Apte (St. Louis/USA)
Animal model for AMD interfering lipid trafficking

31 P
Christian Grimm, F. Storti, T. Hornemann, A. den Hollander, C. Maugeais
(Schlieren/CH, Nijmegen/NL, Basel/CH)
Impaired function of the lipid transporters ABCA1 and ABCG1 in the RPE leads to an AMD-like phenotype in mice

32 L
Nicolas Bazan (New Orleans/USA, Stockholm/S)
Elovanoids are novel photoreceptor survival signals relevant to AMD

33 L
Clare Futter (London/GB)
Lysosome dysfunction in the RPE and its role in early AMD

34 L
Gerard A. Lutty, S. Ogura, R. Baldeosingh, D.S. McLeod, M.M. Edwards, I.A. Bhutto (Baltimore/USA)
Mast cell involvement in geographic atrophy

17:40 - 18:00 Lecture in memory of Gerhard Zinser
Moderator:
Frank G. Holz
Daniel Pauleikhoff

35
Josef F. Bille (Heidelberg/D)
Past, present and new horizons in imaging analysis - The heritage of Gerhard Zinser

19:30 - Reception at “Brenner’s Park Hotel”

20:00 - Gala dinner

Saturday, 21th September 2019

08:30 - 10:00 5th Session - Neurobiology of the outer retina II
Moderators:
Thomas Langmann (Cologne/D)
Anneke den Hollander (Nijmegen/NL)

36 L
Janet Sparrow (Boston/USA)
Is lipofuscin a relevant factor in the pathogenesis of AMD?

37 P
Thomas Ach, K. Bermond, J. A. Gambril, C. Wobbe, A. Berlin,
R. Heintzmann, K.R. Sloan, C.A. Curcio (Würzburg/D, Jena/D, Birmingham/USA)
Cellular and subcellular changes in the RPE: from normal aging to early signs of AMD

38 L
Deborah A. Ferrington (Minneapolis/USA)
Primary RPE cultures from donors with AMD

39 P
Stephanie C. Joachim, N. Wagner, M. Gammel, A. Greulich, S. Reinehr, J. Hurst, H.B. Dick, S. Schnichels (Bochum/D, Tübingen/D)
Novel porcine organ culture model for AMD research

40 L
Anneke den Hollander (Nijmegen/NL)
Understanding disease mechanisms in AMD: From serum biomarkers to an organ-on-a-chip model for AMD

41 L
John G. Flannery, M.H. Berry, A. Holt, A. Salari, J. Veit, M. Visel, J. Levitz, K. Aghi, B. Gaub, B. Sivyer, E. Isacoff
(California/USA, Oregon/USA, New York/USA, Zürich/CH)
Restoration of high-sensitivity and adapting vision with a cone opsin

42 L
Volker Busskamp (Bonn/D)
Programming human stem cells to cone photoreceptors

43 P
Giuliana Gagliardi, D.M. Feitosa-Afonsso, Y.B. Arik, J. Heesterbeek, C.B. Hoyng, A.D. van der Meer, A.I. den Hollander
(Nijmegen/NL, Enschede/NL)
Using human-induced pluripotent stem cells for modelling the blood-retinal-barrier on-a-chip

10:00 - 10:45 6th Session - Rapid Fire Presentations

11:15 - 13:00 7th Session - Phenotyping AMD: Advances in Imaging
Moderators:
Richard F. Spaide (New York/USA)
Giovanni Staurenghi (Milan/I)

44 L
SriniVas Sadda (Los Angeles/USA)
Choriocapillaris status as a risk factor in AMD

45 L
Philip J. Rosenfeld (Miami/USA)
Choriocapillaris imaging using SS-OCT angiography in AMD

46 P
Martin Hammer, R. Schultz, D. Meller (Jena/D)
Clinicopathologic comparison of fluorescence lifetimes and spectral characteristics in AMD

47 L
Sebastian Wolf, C. Dysli, M.S. Zinkernagel (Bern/CH)
Fluorescence lifetimes in AMD

48 P
Lydia Sauer, A.S. Vitale, N.K. Modersitzki, E.D. Hansen, C. B. Komanski, P.S. Bernstein (Salt Lake City/USA)
Imaging of AMD with FLIO

49 L
Adam Dubis (London/GB)
Adaptive optics photoreceptor imaging, function and survival in AMD

50 P
Thomas Theelen, P.P.A. Dhooge, T.W.F. Mulders, C.B. Hoyng (Nijmegen/NL)
In vivo photoreceptor imaging by non-adaptive optics confocal scanning laser ophthalmoscopy

51 P
R. Theodore Smith, K.B. Freund (New York City/USA)
Quantitative fundus autofluorescence (qAF) of GA secondary to AMD

52 L
Daniel F. Martin (Cleveland/USA)
Why did GA trials fail - how to overcome obstacles?

53 P
Victor Chong (Ingelheim/D)
Neuroprotection as a therapeutic option for GA

13:00 - 14:00 - Lunch

14:00 - 17:30 8th Session - Dissecting AMD: Novel approaches
Moderators:
Frank G. Holz (Bonn/D)
Daniel Pauleikhoff (Mpnster/D)

54 L
Adnan Tufail (London/GB)
Application of deep learning-based automated segmentation in OCT on AMD

55 L
Aaron Lee (Washington/USA)
Deep learning applications with OCT in AMD

56 L
Karl Csaky, M. Oulette, C. Clark (Dallas/USA, Plano/USA)
Developing human based intuitive deep learning
algorithms for analyzing intermediate AMD OCT-Images

57 L
Glenn J. Jaffe (Durham/GB)
Challenges of clinical relevant phenotyping of exudative AMD

58 L
Richard F. Spaide (New York/USA)
OCT-angiography – dissecting neovasular AMD

59 L
Giuseppe Querques, R. Sacconi, V. Capuano, A. Carnevali, D. Colantuono, M. Battista, E. Borrelli,
A. Miere, M.Parravano, E. Costanzo, L. Querques, E.H. Souied, F. Bandello
(Milan/Creteil/F, Catanzaro/I, Rome/I)
„Quiescent“ CNV in AMD – characteristics and consequences

60 P
Maximilian Pfau, L. von der Emde, C. Dysli, P.T. Möller, S. Thiele, M. Lindner, M. Schmid,
S. Schmitz-Valckenberg, F.G. Holz, M. Fleckenstein
(Bonn/D, Bern/CH, Oxford/GB)
Type-1 choroidal neovascularization reduces the progression of atrophy in eyes with AMD

61 L
David Sarraf (Los Angeles/USA)
Mechanisms and pathways of PED development in neovascular AMD

62 L
K. Bailey Freund (New York City/USA)
Type 3 CNV – a specific phenotype?

63 L
John Marshall (London/GB)
Can a nanosecond beam modulated laser improve transport mechanisms and delaying progression towards late AMD?

64 L
Robyn Guymer - LEAD study team (Melbourne/AUS)
Natural history and modulation of drusen by laser:
The LEAD randomized controlled trial of sub-threshold nanosecond laser intervention in AMD

65 L
Eric Souied (Paris/F)
Scarring of CNV – differentiation by multimodal imaging?

66 L
Daniel Pauleikhoff, M.L. Farecki, H. Faatz, K. Rothaus, G. Spital, A. Lommatzsch (Münster/D)
Mathematical characterization of CNV before and under anti-VEGF-therapy

67 L
Usha Chakravarthy, B. Reeves, R. Evans, C. Rogers (Belfast/GB, Bristol/GB)
Extended follow up from the IVAN trial

68 P
Heinrich Gerding (Olten/CH)
10 years anti-VEGF treatment outcomes on neovascular AMD

69 L
Ricarda G. Schumann, V. Deiters, S.R. Günther, D. Vogt, J. Siedlecki, S.G. Priglinger (Munich/D)
Long-term visual acuity outcomes and anatomic results from anti-VEGF-therapy in patients with neovascular AMD in a real-life setting

70 P
Jakob Siedlecki, C. Fischer, B. Schworm, T.C. Kreutzer, K. Kortüm, R. Schumann, A. Wolf, S.G. Priglinger (Munich/D)
Long-term incidence of macular atrophy and clinical outcomes in neovascular AMD managed to sub-retinal fluid only

17:30 Adjourn
Frank G. Holz
Daniel Pauleikhoff

Rahmenprogramm

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