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Vitreous Hyalocytes – new insights from old friends

Symposium im Rahmen der DOG 2021 online
Online, Deutschland
Veranstaltungsnummer: 37060
Zertifizierung: beantragt
Gebühren ab: gebührenfrei
verfügbare Plätze: unbegrenzt
Sprache: Englisch

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  • Datum
    30.09.2021, 17:00 - 17:45
    DOG - Deutsche Ophthalmologische Gesellschaft e.V.
    This symposium will bring together leading scientists and clinicians from the fields of development, genetics, molecular biology and immunology, who have a common interest in hyalocytes and their role in retinal diseases.


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  • Vorsitzende
    Organisator / Vorsitzender: C. Lange, Freiburg
    Vorsitzende/r: J. Sebag, Los Angeles, United States


    Hyalocytes represent a unique and distinct innate immune cell population, which is specialized and adapted to the tissue-specific needs of the human vitreous body. Although first described in 1840 by Hannover, little is known about the biology and function of hyalocytes in the human eye. This is mainly due to their scarcity, which in the past made comprehensive studies impossible. Recent advances in technology have made it feasible to shed more light on this fascinating immune cell population and indicate that hyalocytes are an underestimated mediator in vitreoretinal diseases and for the immune privilege of the eye.
    17:00 – 17:09
    Do12-01 - Vitreous and Hyalocytes in Health and Disease
    Referent/in: Jerry Sebag, Los Angeles, United States

    Hyalocytes are mononuclear phagocytes that reside within the cortical vitreous, 50 - 75 uM anterior to the retina where they act as sentinel cells of the reticuloendothelial system of the body. Following posterior vitreous detachment (PVD), hyalocytes are displaced far from the retina and can no longer play their important physiologic role(s), with possible untoward influences on retinal health. Anomalous PVD with vitreoschisis more than 75 uM from the retina leaves hyalocytes attached to the fundus where they play an important role in proliferative vitreo-retinopathies, most notably macular pucker but also proliferative vitreo-retinopathy following retinal detachment.

    17:09 – 17:18 
    Do12-02 - News from old friends - RNASeq characterization of vitreal hyalocytes
    Referent/in: Clemens Lange, Freiburg

    Human hyalocytes represent a unique and distinct innate immune cell population specialized and adapted for the tissue-specific needs in the human vitreous. Vitreal hyalocytes are characterized by a strong expression of genes related to antigen processing and presentation as well as immune modulation. Thus, hyalocytes may represent an underestimated mediator in vitreoretinal disease and for the immune privilege of the eye.

    17:18 – 17:27 
    Do12-03 - Hyalocytes as a new cellular component of the ocular innate immune system
    Referent/in: Peter Wieghofer, Leipzig

    The complexity of the eye consisting of distinct compartments inhabited by a diverse range of cell types is also reflected by the heterogeneity of ocular macrophages. The nature of these innate immune cells remains poorly understood, in particular from a developmental point of view. Recent advancements in murine transgenic fate mapping models now open the possibility to investigate the origin and turnover of resident ocular tissue macrophages, like hyalocytes.

    17:27 – 17:36 
    Do12-04 - The role of hyalocytes in diseases of the vitreoretinal interface
    Referent/in: Ricarda Schumann, München
    17:36 – 17:45 
    Do12-05 - Hyalocytes in proliferative diabetic retinopathy
    Referent/in: Stefanyia Boneva, Freiburg

    Next generation RNA sequencing reveals considerable differences in the expression profile of hyalocytes isolated from diabetic and control patients. Hyalocytes from patients with proliferative diabetic retinopathy seem to not only eliminate blood constituents in aging vitreous bleeding, but also undergo transdifferentiation to myofibroblasts. Hyalocytes may represent a so far underestimated target for future clinical assessment in proliferative diabetic retinopathy.

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